Abstract: Objective To investigate the association of cerebral hyperperfusion syndrome(CHS) with age and vascular stenosis severity in patients with carotid artery stenting. Methods From January 2011 to December 2015, 257 patients with carotid artery stenting were selected as the subjects. Before operation, transcranial Doppler ultrasound was used to investigate the basic blood flow of the patients, the postoperative 1, 12, 24 h and the bedside TCD examination were compared with the preoperative examination results, According to the results of TCD examination, 257 patients were divided into CHS group(13 cases) and control group(244 cases) without CHS group, to analyze the correlation between the incidence of high perfusion syndrome after carotid artery stenting and age, systolic blood pressure and vascular stenosis. Results The incidence of CHS was 5.1%(13/257) in patients with carotid artery stenting, with the increase of age, systolic blood pressure and vascular stenosis, the incidence of CHS increased gradually(χ²=17.973, 24.357, 23.488, all P<0.001). Conclusion High perfusion syndrome is a rare but serious complication after carotid artery stenting. The patients who are older, more than 170 mm Hg(1 mm Hg=0.133 kPa), and the degree of stenosis more than 90% are more likely to occur. In clinical work, the change of blood pressure should be closely observed and strict control of blood pressure, especially in elderly patients with stenosis of blood vessels, is the nursing key to prevent and reduce the occurrence of high perfusion syndrome.