Abstract: Objective To explore the clinical efficacy of phlegm and blood stasis therapy combined with nursing intervention in the treatment of hypertensive headache and its impact on patients' quality of life and nursing satisfaction. Methods Eighty-six patients with hypertensive headache admitted to Lishui Hospital of Traditional Chinese Medicine from March 2017 to March 2019 were randomly divided into control group(n=43) and observation group(n=43). The control group was treated with routine treatment, while the observation group was treated with Sheyi rubbing therapy. Two groups of patients were given comprehensive nursing intervention. The clinical efficacy of the two groups and the blood pressure, the frequency of headache attacks, and the brachial artery blood flow-mediated diastolic function were compared before and after treatment. The health status survey form(SF-36) was used to evaluate the quality of life of patients before and after treatment. Results The total effective rate was significantly higher in the observation group than that in the control group(95.35% vs. 81.40%, χ²=4.074,P<0.05). The frequency of headache attacks after treatment in the observation group [(1.85±1.02) times/month vs.(2.96±1.36) times/month], diastolic blood pressure [(76.93±8.66) mm Hg vs.(84.36±7.15) mm Hg] and systolic blood pressure [(126.18±13.29) mm Hg vs.(132.45±14.45) mm Hg] was significantly lower than that of the control group, and the brachial artery blood flow-mediated diastolic function rate [(6.48±1.25)% vs.(5.32±1.62)%] was significant higher than that of the control group(all P<0.05). The scores of the SF-36 scale in the observation group were significantly higher than those in the control group(all P<0.05). Conclusion The combination of phlegm and blood stasis therapy in the treatment of hypertensive headache is effective, which can significantly reduce the headache frequency, improve hypertension and vascular endothelial dysfunction, and improve the quality of life.