Abstract: Objective To investigate the prevalence of metabolic syndrome(Mets) and the changes of hormone levels in perimenopausal women of uygur nationality in Urumqi. Methods A total of 367 uygur perimenopausal women who were admitted to the first affiliated hospital and physical examination center of Xinjiang Medical University from January to June 2018 were selected as research objects. According to the menstrual state, the patients were divided into pre-menopausal group(61 cases), perimenopause group(244 cases) and early postmenopausal group(62 cases). The changes of Mets hormone levels in different menstrual states were compared and analyzed. Results ① The incidence of Mets was 16.1% in uygur women aged 40-60 years in Xinjiang. The incidence rate of postmenopausal women(22.6%) was higher than that of premenopausal women(4.9%) and perimenopausal women(17.2%). ② There was no statistically significant difference in sex hormone levels between each case group and the control group before menopause. There was no significant difference in FSH, LH and T(P>0.05), while there was significant difference in E2 and E2/T(all P<0.05) between the perimenopausal metabolic group and the control group. Compared with the control group, E2/T in the Mets group and the early postmenopausal group was statistically significant by U test(P<0.05). ③ There were statistically significant differences in FSH, E2, E2/T between perimenopausal and early postmenopausal Mets groups(all P<0.05). Conclusion The prevalence of Mets increases with the change of menopause. The prevalence of postmenopausal early group is higher than that of premenopausal and perimenopausal women. The occurrence of metabolic syndrome may be related to the decrease of E2 and the increase of E2/T in the perimenopause group, and the imbalance of E2 and T in the early postmenopausal group.