Abstract: Objective To investigate the clinical values of enhanced recovery after surgery(ERAS) in the perioperative period of pediatric colonic lesions using retrospective study. Methods Thirty children with colonic polyps or duplication of colonic who underwent ERAS(ERAS group) and 30 children with colonic polyps or duplication of colonic treated by traditional methods(control group) in the second ward of general surgery of He'nan Children's Hospital from July 2013 to May 2017 were selected using random number table method. Postoperative indicators(defecation time for the first time, length of hospital stay, hospitalization fee) and postoperative relevant complications(upper respiratory tract infection, sore throat, urethral pain, adhesive intestinal obstruction, anastomotic leakage, wound infection) were compared. All data were analyzed using SPSS 17.0 statistical software. Results The defecation time for the first time, the length of hospital stay and the hospitalization fee in the ERAS group were significantly lower than those in the control group(all P<0.05)[defecation time for the first time(1.65±0.17) d vs.(2.41±0.19) d, length of hospital stay[7.00(6.00,8.00)d vs. 7.80(6.97,11.00)d], hospitalization fee(12 126.97±1 367.56) yuan vs.(14 155.67±1 686.22) yuan. At the same time, the occurrences of upper respiratory tract infection, sore throat, urethral pain, adhesive intestinal obstruction in the ERAS group were significantly lower than those in the control group(all P<0.05). The occurrences of upper respiratory tract infection 3 cases vs. 10 cases, the occurrences of sore throat 2 cases vs. 8 cases, the occurrences of urethral pain 2 cases vs. 9 cases, the occurrences of adhesive intestinal obstruction 0 case vs. 5 cases. In addition, there were no significant differences in the occurrences of adhesive intestinal obstruction, the occurrences of anastomotic leakage and incision infections(all P>0.05). Conclusion ERAS is safe and reliable in the process of pediatric colon surgery, which can effectively promote the recovery of postoperative gastrointestinal function and reduce the occurrence of complications.