Abstract: Objective To study the intervention effect of oxycodone and parecoxib sodium on patients undergoing nasal endoscopic surgery, and to provide data reference for clinical application. Methods Eighty patients who underwent endoscopic sinus surgery in our hospital from April 2016 to April 2018 were selected and randomly divided into parecoxib sodium group and combined group with 40 cases in each group. The parecoxib sodium group was given parecoxib sodium(40 mg) 30 minutes before induction of anesthesia, and the combined group was given oxycodone(10 mg) on the basis of parecoxib sodium group. The indexes of entering the operating room(T0), at the end of operation(T1), at the end of extubation(T2), and when leaving the operating room(T3) were counted. Results In the T3 period, HR(61.75±12.18) times/min, SBP(106.62±10.63) mm Hg, DBP(66.62±8.15) mm Hg, SPO₂(94.89±0.84)%, IL-2(15.16±1.92) pg/L, IL-4(20.12±2.22) pg/L, IL-5(42.86±2.82) pg/L, and IL-17(3.51±1.16) pg/L of the combined group were lower than those of the parecoxib group(79.45±10.15) times/min,(124.86±11.45),(76.62±8.96) mmHg,(98.78±1.26)%,(21.45±2.10),(29.26±2.45),(48.98±3.89),(5.95±1.31) pg/L(all P<0.001). The score of agitation, VAS score and extubation time in the combined group were lower than those in the parecoxib group(all P<0.05). Conclusion Oxycodone combined with parecoxib sodium can reduce restlessness during anesthesia recovery, improve pain and serum inflammatory factors levels.