Abstract: Objective To explore the clinical value of combined detection of troponin T(cTnT), C-reactive protein(CRP) and amino-terminal brain natriuretic peptide(NT-proBNP) in early diagnosis of chronic heart failure(CHF), and provide reference for early diagnosis of CHF. Methods Ninety patients with CHF in Haikou Third People's Hospital from May 2015 to May 2017 were selected as observation group. Sixty healthy people were selected as control group during the same period. The levels of cTnT, CRP and NT-proBNP of the two groups were measured, and the differences of three indicators in different NYHA grades with CHF patients were compared. Results The higher the NYHA grade, the higher the content of the three indicators. There were significant difference among different grades(all P<0.05). The CRP and NT-proBNP indicators of NYHA-I patients were significantly higher than those of healthy group(P<0.05), and there was no significant difference in cTnT indicators between the two groups(P>0.05). Spearman rank correlation analysis indicated that the cardiac grading showed a significant positive correlation with NT-proBNP, CRP and CTnT(r=0.875, 0.412, 0.312, all P<0.05). Conclusion NT-proBNP is an important indicators for evaluating cardiac function. Combined detection of cTnT, CRP and NT-proBNP can accurately diagnose CHF patients, and can grade different degrees of disease, providing reliable basis for clinical treatment.