Abstract: Objective To analyze the effect of comprehensive application of multiple chronic disease management models in elderly hypertension patients in community, and provide basis for improving the effect of community prevention and control of chronic diseases. Methods According to the simple random sampling method, 120 elderly patients with hypertension were selected from the newly established chronic disease management files in the community health service center. The patients were randomly divided into intervention group(n=60) and control group(n=60). The control group was managed according to the Health Management Service Standard of Hypertension patients, on the basis of which the intervention group was integrated into self-management, group management, family intervention and peer education. Six months later, the self-management behavior scale of hypertension patients, hypertension self-efficacy scale, self-rating anxiety scale and hypertension related knowledge questionnaire were used to evaluate two groups of patients. Results The awareness rate of hypertension-related knowledge in the intervention group was higher than that in the control group. The total score of self-management behavior evaluation(124.50±17.32), self-efficacy score(63.33±7.02) in the intervention group were higher than those in the control group(113.77±20.65, 58.12±8.68). The average blood pressure in the intervention group[(132.63±7.14)/(74.40±7.46)] was lower than that in the control group[(140.48±10.69)/(78.53±7.58)], and the anxiety score in the intervention group(54.15±8.40) was lower than that in the control group(59.41±9.10), the above difference was statistically significant(all P<0.05). The self-efficacy of the intervention group was negatively correlated with anxiety level(r=-0.288, P=0.025) and positively correlated with self-management behavioral capacity(r=0.382, P=0.003). The most influential factor for self-efficacy was the level of self-management(P<0.01), followed by anxiety(P<0.05). Conclusion The comprehensive application of multiple chronic disease management models in the daily management of elderly patients with hypertension will help them master the knowledge of disease, promote their emotional improvement, improve their self-management ability, and promote the long-term improvement of healthy behavior through the promotion of self-efficacy.