Abstract: Objective To retrieve the randomized controlled trials of traditional Chinese medicine nursing intervention for patients with coronary heart disease and anxiety and depression published in recent years, and systematically evaluate the efficacy of traditional Chinese medicine nursing intervention for patients with coronary heart disease and anxiety and depression. Methods Through electronic and manual searches, we searched the published literature on clinical research of patients with coronary heart disease and anxiety and depression in TCM nursing intervention from 2009 to 2018, screened the literature, formulated inclusion and exclusion criteria, and included qualified clinical studies according to the criteria, and determined the total effective rate, SAS score, SDS score and HAMD score as outcome indicators. Review Manager 5.3 software and Stata 14.0 software were used to test the heterogeneity of the data, merge the effects, publication bias analysis, and complete meta-analysis. Results A total of 176 relevant literatures were retrieved. According to the inclusion criteria and exclusion criteria, 11 studies were finally included. A total of 1079 cases were included, including 560 cases in the experimental group and 519 cases in the control group. The quality of the literature was evaluated, and the results showed that the quality of the literature was general. Meta-analysis results showed that the levels of Total efficiency(OR=4.23, 95% CI:2.36 to 7.60, P<0.001), SAS(WMD=-8.70, 95% CI:-14.74 to-2.66, P=0.005), SDS(WMD=-9.11, 95% CI:-11.36 to-6.85, P<0.001), HAMD(WMD=-5.41, 95% CI:-6.07 to-4.74, P<0.001]. All the results were statistically significant. Heterogeneity test results showed that the total effective rate and HAMD score for each study were P>0.10, which was homogenous. SAS score and SDS score were P<0.10 for each study, which was heterogeneous. Egger test showed that P=0.092, indicating that there was less possibility of publication bias. Conclusion Chinese medicine nursing has obvious improvement effect on patients with coronary heart disease and anxiety and depression. However, due to the quality of the included literature, further improvement in quality is needed to confirm.