Abstract: Objective To study the application experience of fine nursing in weaning of mechanical ventilation and its influence on the time of mechanical ventilation, the success rate of one-time evacuation and complications. Methods Total 92 patients who were treated by mechanical ventilation in Quzhou people's hospital from June 2016 to June 2018 were divided into two groups according to the different nursing methods, 46 cases in each group. The routine group was given routine nursing, and the fine nursing group was given fine nursing on the basis of the routine group. The nursing effect, complication rate and patient compliance rate were counted. Results After 4 weeks of nursing, the levels of PaO₂ and SaO₂ in the fine nursing group were higher than those in the routine group, and the scores of PaCO₂, HR, RR, SAS, SDS and Apache were lower than those in the routine group(all P<0.05). The mechanical ventilation time of the fine nursing group was(4.89±1.02) d, shorter than that of the routine group(10.52±1.62) d(t=19.950, P<0.001). The one-time weaning success rate of the fine nursing group was 78.26%(36/46), higher than that of the routine group 58.70%(27/46), χ²=4.079, P=0.043. The complication rate of the fine nursing group was 10.87%(5/46), significantly lower than that of the routine group 28.26%(13/46), χ²=4.420, P=0.036. The compliance rate of the fine nursing group was 95.65%(44/46), higher than that of 82.61%(38/46) in the control group(χ²=4.039, P=0.044). Conclusion Fine nursing can reduce the time of mechanical ventilation, improve the success rate of one-time weaning and reduce complications.