Abstract: Objective To investigate the clinical effect of Mudan Granule in reconstructing lower limb blood transport and nerve conduction of diabetic foot patients undergoing tibial lateral bone transfer. Methods A total of 32 patients with diabetic foot admitted to the hospital from October 2017 to December 2018 were selected and divided into control group and experimental group using random number table method, with 16 cases in each group. All patients were received transverse tibial bone transport. After operation, the experimental group were received Mudan Granule orally and the control group were received placebo for 8 weeks. Ulcer healing time, foot skin temperature, VAS pain score, blood flow velocity of dorsal foot artery, total peroneal nerve sensation, motor conduction velocity, peripheral blood VEGF and PDGF levels of patients were compared between the two groups. The complications and adverse reactions during treatment were recorded. Results All 32 cases were followed up for an average of 5.6 months(4-9 months). Compared with the control group, the ulcer healing time of the experimental group was significantly shortened. The improvement of skin temperature, blood flow velocity of dorsal foot artery and relief degree of postoperative pain symptoms of the experimental group were better than the control group. Meanwhile, the total peroneal nerve sensory, motor conduction velocity and the level of peripheral blood cytokines of the experimental group were increased compared with the control group(all P<0.05). Conclusion After tibial lateral bone transfer, oral administration of Mudan Granules can effectively relieve pain, improve the hemodynamic index and promote the nerve conduction and rapid healing of ulcer wound. Meanwhile, it has certain effect in preventing ulcer recurrence and fracture formation, which may be a good complementary and intensive treatment for diabetic foot patients after transverse tibial bone transport.