重组人干扰素α-2b喷雾剂联合热毒宁治疗小儿手足口病的疗效分析

王凯; 孔慧霞; 刘静炎; 刘磊; 张艳华; 高东培; 徐发林

doi:10.16766/j.cnki.issn.1674-4152.001298

重组人干扰素α-2b喷雾剂联合热毒宁治疗小儿手足口病的疗效分析

doi: 10.16766/j.cnki.issn.1674-4152.001298

1. 郑州大学附属郑州中心医院新生儿科, 河南郑州 450000;
2. 郑州大学第三附属医院新生儿科, 河南郑州 450052〖JP〗

基金项目:

河南省2017年度科技发展计划项目(172102310205)

2015年度河南省医学科技攻关计划(201502013)

详细信息

通讯作者:
王凯,E-mail:185269081@qq.com

中图分类号: R512.5
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出版历程
- 收稿日期: 2019-08-05
- 网络出版日期: 2022-08-05

Efficacy analysis of recombinant human interferon α-2b spray combined with Reduning injection in the treatment of children with hand, foot and mouth Disease

Department of Neonatology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450000, China

摘要

摘要: 目的探讨重组人干扰素α-2b喷雾剂联合热毒宁对小儿手足口病免疫功能及血清炎性因子的影响。方法将2016年2月—2018年8月郑州市中心医院收治的340例手足口病患儿按随机数字法分为2组,每组170例。对照组给予重组人干扰素α-2b喷雾剂(20 mL,3次/d),观察组在对照组基础上给予热毒宁(0.6~0.8 mL/kg,1次/d)。使用SPSS 23.0统计学软件进行数据处理并比较2组治疗前后临床体征、免疫功能与血清炎性因子水平。结果治疗后,观察组退热时间[(0.97±0.16)d]短于对照组[(1.75±0.39)d,t=-24.125,P<0.001],皮疹消退时间、口腔溃疡愈合时间及住院时间均短于对照组(均P<0.05)。治疗后,2组CD4⁺、CD4⁺/CD8⁺、CD8⁺水平改善(均P<0.05),且改善效果观察组优于对照组(均P<0.05)。治疗后,2组IgM、IgG及IgA水平均升高(均P<0.05),且观察组高于对照组(均P<0.05)。治疗后,2组血清CRP、IL-4及IL-6水平降低(均P<0.05),且观察组低于对照组(均P<0.05)。结论重组人干扰素α-2b喷雾剂联合热毒宁治疗小儿手足口病可明显改善患者临床体征,增强患儿免疫功能,降低患儿血清炎性因子水平,疗效显著,有助于患儿康复。
- 手足口病 /
- 热毒宁针 /
- 重组人干扰素α-2b喷雾剂 /
- 免疫功能
Abstract: Objective To investigate the effect of recombinant human interferon α-2 b spray combined with Reduning injection on immune function and serum inflammatory factors in children with hand, foot and mouth disease. Methods A total of 340 children with hand, foot and mouth disease admitted to Zhengzhou Central Hospital from February 2016 to August 2018 were randomly divided into two groups according to random number method, each group of 170 cases. The control group was treated with recombinant human interferon α-2 b spray(20 mL, 3 times/day), and the observation group was treated with Reduning injection on the basis of the control group(0.6-0.8 mL/kg, 1 time/day). SPSS 23.0 statistical software was used to process the data and compare the clinical signs, immune function and serum inflammatory factors of the two groups before and after treatment. Results After treatment, the antipyretic time of the observation group(0.97±0.16) d was lower than that of the control group(1.75±0.39) d(t=-24.125, P<0.001), and the time of rash regression, healing time of oral ulcer and hospitalization time were shorter than those of the control group(all P<0.05). The levels of CD4⁺, CD4⁺/CD8⁺, and CD8⁺ were improved in the two groups(all P<0.05), but the improvement effect was better in the observation group than those in the control group(all P<0.05). The IgM, IgG and IgA levels in the two groups were significantly increased(all P<0.05), but the levels in the observation group were significantly higher than those in the control group(all P<0.05). The serum levels of CRP, IL-4 and IL-6 in the two groups were significantly reduced(all P<0.05), but the levels in the observation group were significantly lower than those in the control group(all P<0.05). Conclusion Recombinant human interferon alpha-2 b spray combined with Reduning injection in the treatment of pediatric hand, foot and mouth disease can significantly improve the clinical signs, enhance the immune function of children, and reduce the level of serum inflammatory factors. The curative effect is significant, conducive to the recovery of children.
- Hand /
- foot and mouth disease /
- Reduning injection /
- Recombinant human interferon α-2b spray