Abstract: Objective To observe the effect of pituitrin combined with hysteroscopic negative pressure cleaning on the recovery and adverse reactions of type Ⅱ cesarean scar pregnancy. Methods A total of 180 cases of type Ⅱ cesarean scar pregnancy whom were admitted to obstetrics department of Luzhou maternal and child health hospital from April 2017 to April 2019 were as the research object, all the patients were divided into control group(n=90) and research group(n=90) according to random number table method. The patients in the control group were treated with bilateral uterine artery embolization combined with hysteroscopy negative pressure uterine clearance, while the patients in the study group were treated with pituitrin injection combined with hysteroscopy negative pressure uterine clearance. The operation duration, intraoperative bleeding volume, postoperative vaginal bleeding duration, hospitalization time, β-hCG recovery time, postoperative menstrual recovery time, menstrual recovery cycle and menstrual duration were counted, and the adverse reactions were observed. Results The amount of bleeding during uterine clearance in the study group[(23.67±3.47)mL] was significantly less than that in the control group[(34.81±6.95)mL], the duration of vaginal bleeding after operation[(5.84±1.62)d] and the length of hospitalization[(5.07±1.38)d] were significantly shorter than those in the control group[(9.36±2.49) d and(8.42±2.01) d, all P<0.001].The recovery time of menstruation in the study group[(37.96±3.85)d] were significantly shorter than those in the control group[(42.72±4.03)d, t=-8.825, P<0.001]. The incidence of the adverse reactions of the study group(1.11% and 0.00%) was significantly lower than that of the control group(8.89% and 6.67%, χ²=4.211, 4.310, P=0.040, 0.038). Conclusion Compared with bilateral uterine artery embolism, hysteroscopic negative pressure hysteroscopy after pituitrin injection can significantly reduce intraoperative bleeding, shorten the recovery period after operation, promote menstruation and ovulation recovery, reduce the incidence of adverse reactions after operation, which is safe and worthy of clinical application.