Abstract: Objective To study and evaluate the effect of intervening measures on the mental health, quality of life and blood glucose by conducting both routine treatment and community-based psychological intervention on type 2 diabetics. Methods A group of 180 type 2 diabetics was recruited from chronic disease management information system in Kangjian community service center in Shanghai from January 2018 to January 2019. These diabetics were divided into intervention group and control group randomly with random number table method. Besides routine treatment, chronic disease management and health education, the intervention group received periodical community-based psychological intervention that was conducted by family physicians and national psychological consultants biweekly on group and monthly on each individual. All subjects of the two groups were assessed with the methods of SCL-90 and diabetes-specific quality of life scale(DQOL), and their levels of FPG, PPG,HbA1 C were tested before and after the treatment. Results All factors of SCL-90 were statistically significant different from the national norm(all P<0.05). Firstly, we compared the pre-and post-treatment results within the same group. As for SCL-90, in control group the factors except interpersonal sensitivity were statistically significant(all P<0.05), while in intervention group none of the factors was statistically significant(all P<0.05). As for DSQL, in control group, the dimensions except treatment dimension were statistically significant(all P<0.05), while in intervention group none of the dimensions was statistically significant(all P<0.05). Secondly, we compared post-treatment results of the two groups. All the factors of SCL-90 were statistically significant except compulsion, interpersonal relationship and psychosis factors. All the dimensions in DSQL were statistically significant except physiological dimension, and the differences in PPG between the two groups was also statistically significant. Conclusion Family physicians involved community-based comprehensive psychological intervention could improve the mental health and blood glucose, and the quality of life of type 2 diabetics.