Abstract: Objective To study the therapeutic effect of Bushen Zhuangyao extractum combined with Bushen Quyu acupuncture on acute onset of lumbar intervertebral disc herniation. Methods A total of 120 patients with lumbar disc herniation admitted to Hubei Provincial Hospital of TCM due to acute onset from October 2016 to December 2018 were included in the study, who were divided into the observation group and the control group by random number table method, 60 cases in each group. Among them, the control group was treated with Bushen Quyu acupuncture, and the observation group was treated with Bushen Zhuangyao extractum orally on the basis of the control group. The curative effect was observed after 2 weeks of continuous treatment, and the changes of JOA low back pain score, ODI score, serum inflammatory factors and pain-related mediators before and after treatment were compared. Results The total effective rate of the observation group after treatment was 88.3%, which was significantly better than that of the control group(75.0%, χ²=5.604, P<0.05). There were no statistically significant differences in JOA low back pain score, ODI score, the inflammatory factor levels of IL-1β, IL-6, IL-10, TNF-α and the levels of pain-related mediator PGE2, 5-HT, BK, NPY between the two groups before treatment(all P>0.05), which were comparable. Compared with before treatment, the above indicators were significantly improved in both groups after treatment(all P<0.05). Compared with the control group, the above indicators in the observation group were also significantly improved after treatment(all P<0.05). Conclusion Bushen Zhuangyao extractum combined with Bushen Quyu acupuncture for the treatment of acute onset of lumbar intervertebral disc herniation has a significant effect, which can significantly improve the clinical symptoms of patients and reduce the level of inflammatory reaction and pain mediators.