Abstract: Objective To observe the curative effect of prostate decoction number 2 combined with clysis and acupoint application on chronic prostatitis(CP). Methods Total 60 patients with type ⅢA CP admitted to the First Affiliated Hospital of Bengbu Medical College from February 2018 to May 2019 were randomly divided into control group(n=30) and observation group(n=30) by simple randomized grouping method. The control group was given one prostate decoction number 2 of 400 mL(take orally twice in the morning and in the evening). The observation group on the basis of the medication of the control group was given prostate moxibustion type Ⅱ applied Shenque, Qihai, Zhongji alternately, twice a week, once for 12 hours; the rectal drip of traditional Chinese medicine(TCM) was used for treatment, enema was performed continuously in the first 15 days of each month, and then rest for 15 days. The two groups were treated for one month as a course of treatment, three courses in a row. Results The main symptoms of TCM in the two groups was of no significant difference before treatment(all P>0.05). After treatment, compared with those in the control group, the scores for main symptoms like frequent urination, urinary urgency, urinary pain, bulge feeling of perineum, aching feeling of perineum in the observation group were decreased(all P<0.05). The scores of NIH-CPSI and SAS in the two groups had not significantly difference before treatment(all P>0.05). After treatment, compared with those in the control group, the scores of NIH-CPSI and SAS were decreased in the observation group(all P<0.05). The leukocyte count and lecithin body in prostate fluid count of the two groups had no statistically significant differences before treatment(all P>0.05). After treatment, the leukocyte count of prostate fluid in observation group significantly was decreased, while the lecithin body count was increased(all P<0.05). Total effective rate had statistically significant differences(χ²=5.079, P=0.024). Conclusion The effect of prostate decoction number 2 combined with clysis and acupoint application have better effect in treating CP than prostate decoction number 2 alone.