Abstract: Objective To compare the clinical efficacy of Vitapex and triple antibiotic paste(TAP) as root canal disinfectant in pulp revascularization. Methods From January to July 2017, 40 young patients with pulp necrosis or periapical periodontitis in the Department of Dental Pulp, the First Affiliated Hospital of Bengbu Medical College were randomly divided into experimental group(n=20) and control group(n=20). PRF(platelet-richfibrin) enhanced pulp revascularization was performed in both patients. The root canals were disinfected with Vitapex paste in the experimental group and TAP in the control group. The clinical symptoms and fillings were observed at 3 months, 6 months, 9 months and 12 months after operation. Apical films were taken to observe the root development of the affected teeth and measure the root canal length and root canal wall thickness. The clinical effective rate, root canal length, root canal wall thickness and tooth discoloration rate were compared between the two groups. Results The total clinical effective rate was 90.0% in the experimental group and 85.0% in the control group(P>0.05). The root length of the experimental group was(8.74±0.24) mm before treatment and(9.12±0.18) mm after treatment, while that of the control group was(8.81±0.21) mm and(9.21±0.24) mm respectively, with no significant difference between the two groups(P>0.05). The thickness of root canal wall in the experimental group was(2.12±0.32) mm before treatment and(2.66±0.24) mm after treatment, while that in the control group was(2.15±0.28) mm before treatment and(2.71±0.28) mm after treatment, with no significant difference between the two groups(all P>0.05). The tooth discoloration rate was 25.0% in the experimental group and 100.0% in the control group(P<0.05). Conclusion Vitapex and TAP can achieve the same disinfection effect in pulp revascularization of immature permanent teeth, but Vitapex as root canal disinfectant can effectively reduce the discoloration rate of affected teeth.