Abstract: Objective To explore the clinical effect of Aidi injection and cisplatin pleural perfusion combined with pemetrexed disodium in the treatment of lung adenocarcinoma with malignant pleural effusion. Methods Total 68 cases of lung adenocarcinoma with malignant pleural effusion admitted to the Respiratory Department of the Third People's Hospital of Bengbu City from June 2018 to April 2019 were randomly divided into observation group(34 cases) and control group(34 cases). After B-ultrasound exploration and positioning, all patients were placed into the central venous catheter, and then the pleural effusion was detected by B-ultrasound after intermittent drainage. After the pleural effusion was fully drained, the pleural perfusion was performed. On the basis of intravenous application of pemetrexed disodium, the patients in the observation group were given Aidi injection and cisplatin chest perfusion, while those in the control group were given cisplatin chest perfusion. Cisplatin(50 mg/m²) was infused into the thorax 2-3 times a cycle, Aidi injection was given 50 mL each time, twice a week. One month after the end of four cycles of chemotherapy, the clinical efficacy was evaluated by the WHO standard for the efficacy of malignant pleural effusion, the quality of life was evaluated according to the physical KPS score, and the incidence of drug toxicity was evaluated according to the WHO standard for the toxicity and side effects of anticancer drugs. Results In the clinical efficacy, the total effective rate of the observation group(82.35%) was better than that of the control group(58.82%), P=0.033. In the quality of life, the total effective rate of KPS score of the observation group(88.24%) was better than that of the control group(64.71%), P=0.022. In terms of side effects, the incidence of asthenia(P=0.004) and class Ⅲ-Ⅳ side effects(P=0.031) in the observation group was significantly lower than that in the control group. In terms of myelosuppression, liver and kidney function damage, fever, gastrointestinal reactions, there was no significant difference between the two groups(all P>0.05). Conclusion On the basis of cisplatin combined with pemetrexed disodium in the treatment of pleural effusion of lung adenocarcinoma, the use of Aidi injection can improve the clinical effect, reduce the incidence of serious side effects, improve the physical strength and improve the quality of life.