Abstract: Objective To analyze the effect of different blood purification methods on the toxin elimination capacity of patients with maintenance hemodialysis(MHD). Methods Total 80 patients with MHD treated with blood purification in our hospital from January 2015 to April 2018 were divided into low-flux hemodialysis(LFHD) group(n=25), high-flux(HFHD) group(n=31) and hemodiafiltration(HDF) group(n=24) according to the random number table method. The toxin elimination capacity was compared among the three groups. Results ①There was no statistically significant difference in solute clearance among the three groups(P>0.05). ② After treatment, concentrations of serum urea nitrogen(BUN), hippuric acid(HA), p-cresol sulphate(PCS) and indoxyl sulphate(IS) in both groups were significantly decreased. However, there was no obvious change in 3-carboxyl-4-methyl-5-propyl-2-furan-propionic acid(CMPF), and there was no statistically significant difference in the concentration of serum solute among all groups(P>0.05). There were statistically significant differences in declines of HA, PCS, IS and CMPF and the total removal amount of protein-binding toxoid solutes among the three groups(all P<0.05). Besides, the declines of HA, PCS, IS and CMPF and the total removal amount of protein-binding toxoid solutes in HDF group were significantly higher than those in LFHD group and HFHD group(all P<0.05). Conclusion LFHD, HFHD and HDF all can remove toxin, but HDF can clear HA, PCS, IS and CMPF more obviously, which is worthy of clinical attention.