Abstract: Objective To investigate the effect of Danggui Shaoyao Powder on the pre-pregnancy intervention of early recurrent abortion based on the theory of "chronic diseases in collaterals". Methods Using retrospective research method, 60 patients with early recurrent abortion of liver stagnation and spleen deficiency and syndrome of internal blockade of static blood syndrome in the outpatient department of our hospital from February 2015 to August 2017. Based on the theory of "chronic diseases in collaterals", Danggui Shaoyao Powder was added and subtracted for treatment. At the end of the treatment course, the treatment outcome of 60 patients was summarized, and the factors influencing the treatment outcome were analyzed. Results At the end of the course of treatment, 19 patients(31.67%) successfully achieved a natural pregnancy. The results of χ² analysis shown that the number of spontaneous abortion(P=0.013), endometrial type(P=0.027), the abnormal uterine artery blood flow(P=0.034), the main syndrome score of TCM(P<0.001), and the improved endometrium, artery blood flow and the syndrome score of TCM(P<0.05) were correlated with the outcome of treatment, but the course of disease(P=0.558) was not related. Furthermore, logistic regression analysis showed that endometrial type C(P=0.027), abnormal uterine artery blood flow(P=0.034) and TCM main syndrome score ≥ 4(P=0.001) were independent risk factors for the adverse outcome of the treatment. Conclusion The precise syndrome differentiation based on the theory of "chronic diseases in collaterals" can reduce the TCM syndrome scores, significantly improve clinical efficacy.