Abstract: Objective To explore the effect of health education on venous thrombosis self-management in patients with advanced lung cancer based on the "short video+handbook+oral+WeChat" SHOW model. Methods A total of 140 patients who met the inclusion criteria were randomly divided into the experimental group and the control group. Each group has 70 patients. During the hospitalization, the control group used a single form such as a written manual or oral instruction to conduct the mission, while the experimental group used the SHOW model for health education. Both groups of patients underwent the VTE self-management related knowledge test before admission. The VTE self-management related knowledge test is revised according to the survey scale of Green et al., including the degree of recognition of the importance of VTE, the ability to recognize early symptoms and the mastery of relevant first-aid skills. At the time of discharge, the VTE self-management related knowledge test was again performed on the two groups of patients to judge the patient's ability to self-manage venous thrombosis. Results Patients with healthy education in SHOW mode scored significantly higher on VTE than those who received single-form education(4.81±0.39 vs. 4.59±0.55, t=-2.827, P=0.005). The health education in SHOW mode improved more than single form education. The correct rate of response to thromboprophylaxis for venous thrombosis and thrombosis in patients with advanced lung cancer(91.43% vs. 75.71%, χ²=6.295, P=0.021; 91.43% vs. 77.14%, χ²=5.393, P=0.035). In terms of thrombosis risk assessment, symptom identification of thrombosis and pulmonary embolism, both health education methods can improve the self-management ability of venous thrombosis in patients. Conclusion Health education based on SHOW mode can help to strengthen the self-management ability of venous thrombosis in patients with advanced lung cancer, especially in the prevention and emergency treatment of thrombosis.