Abstract: Objective To observe and analyze the clinical effect of electro-oacupuncture combined with acupuncture and cupping in the treatment of post-herpeticneuralgia(PHN). Methods A total of 90 cases of patients with PHN treated in our hospital from February 2017 to February 2019 were selected according to the random table method and randomly divided into observation group and control group(45 cases each group).The observation group line acusector joint thorn cupping therapy 1 time/d for the 10 days for a period of treatment, the treatment of three consecutive period of treatment. The control group patients with oral pregabalin, 75 mg, 2 times/d, to 10 days for a period of treatment, the treatment of three consecutive period of treatment, observe and compare the clinical total effective rate of two groups of patients with treatment. The two groups were compared in terms of pain assessment index(PRI), current pain intensity(PPI), visual analogue score(VAS) and quality of life score. Results The total effective rate was 95.56% in the observation group and 75.56% in the control group. The total effective rate in the observation group was significantly higher than that in the control group(χ²=7.283, P<0.05). The indexes of PRI, PP and VAS in the observation group were significantly lower than those in the control group(P<0.01). The scores of daily life, pain degree, social function, physiological function and mental health in the observation group were significantly better than those in the control group(P<0.01). Conclusion Compared with the clinical treatment of western medicine, electroacupuncture combined with acupuncture and cupping can significantly improve the clinical treatment effect of postherpetic neuralgia, effectively relieve the pain, and improve the quality of life of patients, which is worthy of clinical promotion and use.