Abstract: Objective The incidence of precocious puberty, one of the common diseases currently, increases year by year. By collecting the cases of girls with precocious puberty throughout Shanghai,we applied the TCM syndromes score sheet to determine the main syndromes of precocious puberty, and observed the main syndromes characteristics of precocious puberty to provide the evidence for early detection, diagnosis and treatment, and to provide reference for standardized diagnosis and treatment of precocious puberty in TCM. Methods e analyzed syndromes of 500 girls with precocious puberty from pediatric departments of 6 hospitals throughout Shanghai from January 2013 to June 2016. In accordance to the severity of clinical symptoms by TCM, we scored 0, 2, 4, 6 to match with nil, light, middle, serious, and calculated the scores to summarize the characteristics of TCM Syndrome. There were three types of TCM syndromes, Yin deficiency and Fire prosperity(315 cases, occupied 63.0%), damp-heat smoldering(98 cases, 19.6%) and liver constraint transforming into fire(87 cases, 17.4%).For TCM syndromes, the top ten clinical syndromes(more than 25.0% by frequency) were fear of heat and night sweats, feverishness in palms and soles, swollen breasts, pulse breakdown, dysphoria, dry stool, tidal fever, the mouth swallows dry does, eating too much sweet and greasy food, red tongue with little coating. Conclusion The number of Yin deficiency and Fire prosperity is the largest, while the number of damp-heat smoldering is close to that of liver constraint transforming into fire. The research on the TCM syndrome of girls with precocious puberty is useful to not only observe the early clinical symptoms and early diagnosis, but also provide sounded clues and evidence for diagnosis and prescription.