Abstract: Objective To investigate the current situation of experiential avoidance in patients with total hip arthroplasty, and to analyze the influencing factors to provide theoretical basis for clinical intervention. Methods Using time stage continuous cases the cluster sampling method, 227 patients with total hip arthroplasty at two top three hospitals(Guangzhou Red Cross Hospital, The Second Affiliated Hospital of Guangzhou Medical University) from February to December 2018 were selected. All patients were surveyed by the general questionnaire, Acceptance and Action Questionnaire-2 nd Edition(AAQ-Ⅱ), General Self-Efficacy Scale(GSES) and Social Support Rating Scale(SSRS). Results The experiential avoidance score of patients with total hip arthroplasty was(26.26±7.44) points. Univariate analysis showed that patients with different gender, education, and Harris hip score had statistically significant differences in their experiential avoidance scores(all P<0.05). Pearson correlation analysis showed that the general self-efficacy, social support dimensions and total scores of patients were negatively correlated(all P<0.05). Multiple stepwise regression analysis showed that general self-efficacy, total social support score, Harris hip score, and gender entered the regression equation(F=37.115, P<0.001). Conclusion Patients with total hip arthroplasty have a higher level of experiential avoidance, and gender, Harris hip score, general self-efficacy, and social support influence it. Clinicians should take targeted interventions, implement self-efficacy interventions, and mobilize the patient's social support system to reduce the level of experiential avoidance.