Abstract: Objective Investigate the effect of self-efficacy intervention in improving the care of patients with chronic gastritis. Methods A total of 120 patients with chronic gastritis treated in our hospital from December 2017 to June 2019 were selected and divided into two groups according to the random number grouping method, that is, the control group(n=60) used conventional nursing; the observation group(n=60) used self-efficacy intervention; the two groups were evaluated after 3 months of intervention, and the two groups were compared. Self-efficacy(measurement of self-efficacy assessment scale), health behavior[measurement of health promotion lifestyle scale(HPLP-Ⅱ)], and compliance behavior(measured by our hospital's self-compliance questionnaire) before and after intervention. Results After 3 months of intervention, the scores of self-efficacy(43.51±3.42) in the observation group were higher than those in the control group(37.42±3.40), t=9.786, P<0.05.The scores of healthy behavior(127.96±14.58) were higher than those in the control group(102.51±13.97), t=9.763, P<0.05. The difference of adherence of regular medication, regular review, emotional control, reasonable diet and accurate exercise between the two groups were all statistically significant(Uc=11.580, 7.500, 6.710, 10.210 and 7.070, all P<0.05). Conclusion Self-efficacy intervention can improve self-efficacy, enhance compliance of patients with chronic gastritis, and help patients to establish healthy behaviors. It is of great clinical significance and is worth promoting.