Abstract: Objective To observe the effects of clustering comprehensive nursing intervention on negative symptoms, body weight and BMI in patients with schizophrenia during maintenance. Methods A total of 72 patients with schizophrenia from March 2017 to March 2018 were collected. The patients were randomly divided into observation group and control group,each 36 controls. Patients in the control group were accepted routine nursing intervention. Patients in the observation group were accepted clustering comprehensive nursing intervention. The intervention lasted for 8 weeks.The total scores of PANSS and the scores of various subscales, body weight and BMI between groups were compared. Results The differences of two groups of the total scores of PANSS, negative symptom scores, the weight and BMI[observation group(55.6±8.7) scores,(26.6±8.0) scores,(70.2±6.6) kg,(24.6±2.5) kg/m²; control group(59.4±6.9) scores,(30.9±7.3) scores,(73.8±7.2) kg,(26.2±2.9) kg/m²] were significantly(t=-2.053, P=0.044; t=-2.382, P=0.020; t=-2.211, P=0.030; t=-2.507, P=0.014). The positive symptoms scores and general psychopathological scores[observation group(25.5±6.4) scores,(28.3±7.5) scores; control group(24.7±8.6) scores,(29.0±6.8) scores] were not significant different(t=0.448, P=0.656; t=-0.415, P=0.680) between the two groups. Conclusion Clustering comprehensive nursing intervention for patients with maintenance schizophrenia can effectively improve their scores of PANSS, especially the negative symptoms, and help them manage their body weight and BMI better.