Abstract: Objective To explore the value of continuous nursing based on Omaha System and pharmacist service for prognosis management of Henoch Schonlein purpura nephritis(HSPN). Methods Forty-six children with HSPN who were hospitalized from January 2016 to January 2019 were randomly divided into two groups, 22 in the observation group and 24 in the control group. Routine pediatric nursing was used in the control group, and continuous nursing based on Omaha System and pharmacist service was used in the observation group. The immune indexes, the recurrence rate of nephritis, treatment compliance and nursing satisfaction were compared between the two groups before nursing for 3 months and 6 months after discharge. Results After discharge, the ratio of CD4⁺ T lymphocyte and CD4⁺/CD8⁺ T lymphocyte in the observation group was higher than those in the control group(all P<0.05). There were no significant difference in the levels of CD8⁺ T lymphocyte, IgG, IgM and IgA between the two groups(all P>0.05). The cumulative recurrence rate of HSPN in the observation group was 4.55% at 6 months(P>0.05). The treatment compliance of the observation group was higher than that of the control group(8.33%), P<0.05. The treatment compliance of the observation group were higher than that of the control group at 3 and 6 months after discharge(all P<0.05). The nursing satisfaction of the observation group was 95.45%, and that of the control group was 70.83%, the difference was statistically significant(P<0.05). Conclusion Comparing with the routine nursing, the continuous nursing based on Omaha System and pharmacist service does not significantly improve the immune index of children with Henoch Schonlein purpura nephritis, but there is a trend of relevant changes, and there might be significant differences in the extended follow-up.