Abstract: Objective To explore the preventive and therapeutic effects of medical radiation protector(ork) combined with sulfadiazine silver cream on radiation skin lesions. Methods From January 2017 to December 2018 in Greentown Cardiovascular Hospital, a total of 150 patients with nasopharyngeal carcinoma who received linear accelerator radiotherapy were randomly divided into three groups, 50 cases in each group. Three groups were given different nursing intervention measures. In observation group Ⅰ, the medical radiation protection spray-Oak spray was used in the irradiation area for external use before radiotherapy. In observation group Ⅱ,the medical radiation protection spray-Oak spray was used in the irradiation area for external use before radiotherapy. After radiotherapy, silver sulfadiazine cream was used for external use in the irradiation area. In control group, routine nursing method was adopted. By the end of the total course of treatment, the incidence of skin lesions(incidence, occurrence time, severity) and wound healing(healing time, healing rate) were compared among the three groups. Results The incidence of skin lesions after radiotherapy was 100% in all three groups. There was significant difference in the occurrence time of skin lesions in three groups(F=3.329, P<0.05). The occurrence of skin lesions in group Ⅱ was later. There was significant difference in the degree of skin lesions after radiotherapy among the three groups(P<0.05). The incidence of severe radiation lesions(grade Ⅲ-Ⅳ) was lower in group Ⅱ. The total effective rate of the three groups after treatment and intervention was significantly different(P<0.05), and the clinical effect of group Ⅱ was better. The healing time of skin lesions in three groups was significantly different(P<0.05). The healing time of skin lesions in group Ⅱ was shorter. There was significant difference in the percentage of healed wounds among the three groups(P<0.05). The percentage of healed wounds in group Ⅱ was higher. Conclusion Oxypent combined with silver sulfadiazine can better reduce the incidence of radiation-induced skin lesions and promote the healing of radiation-induced skin lesions in patients with nasopharyngeal carcinoma.