Abstract: Objective To analyze the effect of neuromuscular activation on the clinical treatment of chronic nonspecific low back pain, and to explore the improvement of low back pain, lumbar function and lumbar muscle endurance. Methods A total of 96 patients with chronic nonspecific low back pain admitted to our hospital from August 2018 to August 2019 were selected and divided into group A and group B according to different therapies, 48 in each group. The patients in Group A received routine rehabilitation training and group B received rehabilitation training with neuromuscular activation technology. The clinical effect, VAS score, ODI index and lumbar muscle endurance of the two groups were compared. The data were analyzed by SPSS 22.0 software. Results The total effective rate of group B was 97.92%(47/48), higher than 83.33%(40/48) of group A, the difference was statistically significant(χ²=6.008, P=0.014). The VAS score of the two groups after treatment was lower than that before treatment, the difference was statistically significant(all P<0.05). The VAS score of group B after treatment(1.27±1.16) was lower than that of group A(3.56±1.21), the difference was statistically significant(t=9.465, P<0.001). The ODI index of the two groups after treatment was lower than that before treatment(P<0.05). The ODI index of group B after treatment(9.81±1.33) was lower than that of group A(13.59±1.47), the difference was statistically significant(t=13.211, P<0.001). The static and dynamic lumbar muscle endurance of the two groups were stronger than that of the group before treatment, the difference was statistically significant(all P<0.05). The static and dynamic lumbar muscle endurance of group B after treatment [(84.18±13.05)s,(26.83±7.87)times] was stronger than that of group A [(67.45±15.62)s,(21.47±8.63)times],the difference was statistically significant(t=5.695, 3.179; all P<0.05). Conclusion Neuromuscular activation technology has a significant effect on chronic nonspecific low back pain, which can obviously alleviate the low back pain, improve the lumbar function and improve the endurance of the low back muscle, and it is worthy of clinical application.