糖尿病合并乳腺癌患者超声引导置管感染后Smad 信号通路和凝血因子的表达及意义

曾益林; 袁帅; 唐岩; 孙妍; 陈春亚; 曾志红

doi:10.16766/j.cnki.issn.1674-4152.001424

糖尿病合并乳腺癌患者超声引导置管感染后Smad 信号通路和凝血因子的表达及意义

doi: 10.16766/j.cnki.issn.1674-4152.001424

曾益林^1, ,,
袁帅²,
唐岩³,
孙妍¹,
陈春亚¹,
曾志红⁴

1. 余姚市第二人民医院特检科, 浙江余姚 315400;
2. 浙江大学医学院附属第一医院超声医学科, 浙江杭州 310003;
3. 余姚市第二人民医院乳腺外科;
4. 龙泉市人民医院内分泌科, 浙江龙泉 323700

基金项目:

浙江省医药卫生科研计划项目(2019ZHK102)

详细信息

通讯作者:
曾益林,E-mail:bxzdvd123@163.com

中图分类号: R587.1;R737.9
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出版历程
- 收稿日期: 2019-08-25
- 网络出版日期: 2022-08-06

Expression and significance of Smad signal pathway and coagulation factor in patients with diabetes mellitus and breast cancer after ultrasound-guided catheter infection

Special Survey Division, the Second People's Hospital of Yuyao, Yuyao, Zhejiang 315400, China

摘要

摘要: 目的探讨糖尿病合并乳腺癌患者超声引导置管感染后Smad信号通路和凝血因子的表达及意义。方法选取2013年1月1日—2017年12月31日于余姚市第二人民医院收治的乳腺外科确诊的脑卒中糖尿病合并乳腺癌患者并行超声引导置管患者176例,按照超声引导置管感染是否发生分为感染组和对照组,感染组21例,对照组155例。比较2组患者纤溶酶原激活剂(t-PA)、纤溶酶原激活物抑制剂(PAI-1)、白细胞介素-6(IF-6)、血清凝血酶原时间(PT)、血管内皮生长因子(VEGF)、转化生长因子-β(TGF-β)、凝血酶时间(TT)、纤维蛋白原(FIB)、Smad信号通路相关蛋白的表达及术后并发症发生情况。结果术后1周,感染组的FIB[(3.24±0.16)g/L]、PAI-1[(42.47±2.52)g/L]、TGF-β[(0.61±0.13)μg/L]、VEGF[(0.59±0.12)ng/L]、IF-6[(0.57±0.12)pg/mL]、Smad1[(0.54±0.11)ng/L]、Smad2[(0.53±0.10)ng/L]、Smad3[(0.69±0.15)ng/L]明显高于对照组[FIB(3.01±0.38)g/L、PAI-1(36.02±2.94)g/L、TGF-β(0.48±0.09)μg/L、VEGF(0.36±0.08)ng/L、IL-6(0.44±0.11)pg/mL、Smad1(0.40±0.07)ng/L、Smad2(0.41±0.05)ng/L、Smad3(0.47±0.12)ng/L],均P<0.05,t-PA[(20.28±2.91)ng/L]与对照组[(24.24±3.03)ng/L]相比明显降低(P<0.05)。结论超声引导置管感染发生后可激活Smad信号通路,同时引起凝血功能紊乱。
- 超声引导置管 /
- 感染 /
- 糖尿病合并乳腺癌 /
- Smad蛋白 /
- 凝血功能
Abstract: Objective To investigate the expression and significance of Smad signal pathway and coagulation factor in patients with diabetes mellitus and breast cancer after ultrasound-guided catheter infection. Methods A total of 176 patients with stroke diabetes mellitus and breast cancer diagnosed by breast surgery who were admitted to the second people's Hospital of Yuyao City from January 1, 2013 to December 31, 2017 were divided into infection group and control group according to the occurrence of ultrasound-guided catheter infection. There were 21 patients in infection group and 155 in control group. The expression of plasminogen activator(t-PA), plasminogen activator inhibitor(PAI-1), interleukin-6(IF-6), serum prothrombin time(PT), vascular endothelial growth factor(VEGF), transforming growth factor-β(TGF-β), thrombin time(TT), fibrinogen(FIB), Smad signaling pathway related proteins and postoperative complications were compared between the two groups. Results One week after operation, FIB [(3.24±0.16) g/L], PAI-1 [(42.47±2.52) g/L], TGF-β [(0.61±0.13) μg/L], VEGF [(0.59±0.12) ng/L], IF-6 [(0.57±0.12) pg/mL], Smad1 [(0.54±0.11) ng/L], Smad2 [(0.53±0.10) ng/L] and Smad3 [(0.69±0.15) ng/L] in the infection group were significantly higher than those in the control group(all P<0.05), while t-PA [(20.28±2.91) ng/L] was significantly lower than that in the control group [(24.24±3.03) ng/L, P<0.05]. Conclusion Ultrasound-guided catheterization can activate Smad signal pathway and cause coagulation disorder.
- Ultrasound guided catheterization /
- Infection /
- Diabetes mellitus combined with breast cancer /
- Smad protein /
- Coagulation function