Abstract: Objective To explore the continuous nursing practice program of maintenance hemodialysis(MHD) patients based on comprehensive geriatric assessment and evaluate its effect. Methods From January to December 2018, 94 elderly patients with MHD in Nanjing Drum Tower Hospital were enrolled in this study. According to the random number table method, they were divided into two groups, 47 cases in each group. Routine hemodialysis nursing was carried out in both groups during dialysis. During the non-dialysis period, the control group was given routine continuous nursing, and the observation group was given personalized continuous nursing based on the comprehensive geriatric assessment results of the elderly. Blood biochemical test indexes, complications, quality of life score and ADL score of the two groups were compared before and 6 months after intervention. Results Before intervention, there was no statistically significant difference in the above indexes between the two groups(all P>0.05). After intervention, the total protein [(69.59±14.39) g/L], [hemoglobin(100.34±9.49) g/L] of the observation group were higher than those of the control group [(60.22±16.73) g/L,(88.51±10.39) g/L], urea nitrogen [(100.21±4.43) mg/dL], serum creatinine [(878.50±117.18) μmol/L] were lower than those of the control group [(110.79±5.47) mg/dL,(1 012.23±61.92) μmol/L], the difference was statistically significant(t=18.524, 18.336, 18.471, 18.549, all P<0.05). The incidence of hypertension in the observation group was lower than that in the control group, and the difference between the two groups was statistically significant(P<0.05). The improvement of quality of life scores(72.44±4.82, 67.84±11.42, 63.72±11.37, 74.79±9.68) and ADL score(87.82±9.14) in the observation group were better than those in the control group(60.43±5.69, 54.63±5.67, 58.42±9.91, 68.73±9.38, 54.56±5.47), respectively(t=7.542, 6.770, 8.613, 7. 243, 6.770, all P<0.05). Conclusion The continuous nursing of MHD patients based on the comprehensive geriatric assessment is beneficial to improve the prognosis of patients, reduce the occurrence of complications, and improve the self-care ability and quality of life of patients.