Abstract: Objective To investigate the effect of TCM syndrome differentiation combined with painless management on sleep quality in patients with clavicular fracture, and to analyze the effect of post-traumatic stress disorder. Methods Eighty-four patients with clavicular fractures treated in our hospital from March 20 to March 2019 were enrolled in the study. The Excel random function method was used to divide into the control group and the observation group, and the routine nursing intervention and TCM syndrome differentiation were combined. Painless management of nursing intervention, comparing the sleep quality and psychological status of the two groups of patients. Results The PSQI scores of the control group after intervention were significantly lower than those before the intervention, and there were statistically significant differences(all P<0.05). The PSQI scores of the observation group after intervention were significantly lower than those before the intervention, and there were statistical differences between the groups(all P<0.05), the total score(8.13±2.24) after the intervention was lower than that before the intervention(14.46±3.77), and the difference was statistically significant(t=9.355,P<0.05).After the intervention, the PSQI scores of the observation group were lower than those of the control group in all seven aspects. The total score of the observation group(8.13± 2.24) was lower than the control group(11.85± 2.71, t=6.846, P<0.05). In terms of psychological status, the scores of post-traumatic stress disorder in the observation group were lower than those in the control group(all P<0.05), and the total score of the observation group(36.40±6.77) was significantly lower than that of the control group(62.77±8.94, t=15.239, P<0.05). Conclusion Applying TCM syndrome differentiation and painless management to patients with clavicle fracture can improve their sleep quality, reduce post-traumatic stress disorder and improve their psychological status. It is worthy of clinical application.