Abstract: Objective To investigate the clinical characteristics of female patients with systemic lupus erythematosus (SLE) and bone infarction of knee joint, in order to detect early clinical cases, timely prevention and treatment. Methods A total of 24 female patients with SLE complicated with bone infarction of the knee joint were admitted to the department of rheumatology of our hospital from May 1st, 2015 to September 30th, 2019, and 836 patients with SLE without bone infarction were selected as control group. SLE conformed to the classification criteria established by the American College of Rheumatology in 1997, and bone infarction was diagnosed by MRI. Clinical data of the two groups were collected and analyzed to understand the clinical characteristics of SLE with bone infarction of the knee joint. Results Compared with patients without bone infarction, patients with SLE combined with bone infarction of the knee joint showed statistically significant differences in rash, kidney damage, Reynolds' phenomenon, and hormone shock therapy (P<0.05), while no statistically significant differences in arthritis, serosal inflammation, and blood system involvement (P>0.05). The age of SLE patients with bone infarction was younger[(29.50±7.05) years], the difference was statistically significant between the two groups. Female patients with SLE complicated with bone infarction of the knee joint were associated with rashes, nephropathy, Raynaud's phenomenon, hormone shock therapy. The clinical characteristics of SLE patients with simple bone infarction of the knee joint and SLE bone infarction of the knee joint with other bone infarction showed no statistical significance (P>0.05). Conclusion Female patients with SLE have rash, renal involvement, Raynaud's phenomenon, and glucocorticoid shock therapy, while the age of onset is young. The occurrence of bone infarction of the knee joint should be alert.