Abstract: Objective To analyze and explore the pathogenic risk factors of incisional infection in patients with closed pelvic fractures to guide clinical treatment, in order to reduce the incidence of postoperative wound infection. Methods A total of 406 patients with closed pelvic fractures admitted to Jinhua Central Hospital of Zhejiang Province from April 2013 to May 2019 were enrolled. Twenty-nine patients with postoperative incision infection were enrolled in the infection group, and 377 patients were treated. Patients who did not have a wound infection were placed in the uninfected group. Statistics were performed on acetabular fractures, abdominal injury, BMI, trauma severity score (ISS), operative time, intraoperative blood loss, combined brain trauma, and diabetes mellitus, and were determined by single factor and multivariate analysis. Risk factors for wound infection after closed pelvic fracture, and bacterial culture results were recorded. Results There were 29 cases of incisional infection in 406 patients with closed pelvic fracture, the incidence rate was 7.14% (29/406). Univariate and multivariate logistic regression analysis showed that acetabular fractures (OR=3.111), abdominal injury (OR=3.475), BMI (OR=2.053), and ISS (OR=2.443) The operation time (OR=2.366), intraoperative blood loss (OR=2.777), combined brain trauma (OR=2.254), and diabetes mellitus (OR=3.521) were risk factors for wound infection after closed pelvic fracture. Conclusion Combined with acetabular fracture, abdominal injury, BMI, ISS, operation time, intraoperative blood loss. Volume, combined with traumatic brain injury, and diabetes mellitus are risk factors for postoperative incision infection in patients with closed pelvic fractures. Risk factors should be paid attention to in clinical practice, and preventive treatment should be done early to avoid the occurrence of wound infection after closed pelvic fracture.