Abstract: Objective To investigate the anxiety and depression status of patients with different clinic type of chronic hepatitis B virus infection (HBV) and its influencing factors, and to analyze the influence of disease severity on patients' anxiety and depression status. Methods A total of 257 cases of patients with chronic HBV infection in the Third Affiliated Hospital of Sun Yat-sen University Infectious Diseases department from Oct-2018 to Mar-2019,including chronic hepatitis B (83 cases), liver failure (38 cases), cirrhosis (107 cases), liver cancer (29 cases). SAS and SDS Depression Scale anxiety assessment were given, basic socio-demographic characteristics, biochemical markers and ultrasound data were collected. Single factor analysis method was used to analyze the influencing factors of anxiety and depression in HBV infected patients. Results The incidence of anxiety and depression in patients with different types of chronic HBV infection was 24.5% and 45.9% respectively, especially in patients with liver failure (the incidence of anxiety and depression was 36.9% and 73.7% respectively). The incidence of depression and anxiety in patients with different chronic HBV infection was significantly different. The proportion of moderate & severe depression and anxiety in liver failure patients was significantly higher than others. Among them, mild depression accounts for 50.0%, moderate and major depression accounts for 23.7%, and moderate and major anxiety accounts for 15.8%; The severity of liver disease MELD and child-pugh scores were positively correlated with SAS and SDS, and there were statistically significant differences in depression scores among child-pugh grades A, B and C (all P<0.05), or MELD hierarchy (P<0.05). In addition, gender, cultural level, Medicare payments method and household income was also correlated with the occurrence of depression and anxiety. Conclusion Anxiety or depression in patients with chronic HBV infection are very common, and the severity of the disease is related to anxiety and depression. Women, low educational background, low self-pay and low family income are the influencing factors of anxiety and depression in HBV-infected patients, which should be paid more attention in clinical practice.