Abstract: Objective According to the requirements of family doctor system, to standardize the management of the community osteoporosis patients who signed the contract of "1+1+1", and observe and explore the effective methods of chronic disease management in the community. Methods Total 226 cases of permanent residents in this street diagnosed as "osteoporosis" in the Outpatient Clinic of Wuliqiao Sub-district Community Health Service Center from December 2016 to December 2018 were randomly selected and divided into signed groups and non-signed group. The signed group was given health education, doctor-patient interaction and appointment follow-up. The changes in bone turnover markers, dual-energy X-ray absorptiometry, and Chinese osteoporosis-specific quality of life scales were observed after one year. Results The bone turnover markers β-collagen degradation products, type I procollagen amino terminal propeptide, osteocalcin, parathyroid hormone in the signed group were decreased significantly (all P<0.05), while the hydroxyvitamin D and calcium elevation were increased (all P<0.001). The bone density of waist 1, femoral neck and hip in the signed group were improved (all P<0.05). The Chinese People's Osteoporosis Special Quality of Life Scale (COQOL) in the signed group was significantly lower than that in the non-signed group (all P<0.05). Conclusion Family doctor "1+1+1" contract management not only provides convenient and cheap medical services for patients, but also improves the comprehensive management effect of osteoporosis patients.