Abstract: Objective To analyze and evaluate the advantage and value of the Peguero-Lo Presti voltage standard in the electrocardiographic criteria for the diagnosis of hypertension associated left ventricular hypertrophy (LVH) in adults. Methods Total 138 hypertensive patients were selected from the Second Affiliated Hospital of Wenzhou Medical University from September 2016 to September 2017 to evaluate the accuracy, sensitivity and specificity of traditional Sokolow voltage standard, Cornell voltage standard and Peguero-Lo Presti voltage standard in the diagnosis of LVH based on the echocardiography as the "gold" standard. Results The accuracy of three voltage standards for LVH diagnosis was the highest in Peguero-Lo Presti standard (77.54%), the specificity was the highest in Cornell standard (88.33%), and the sensitivity was the highest in Peguero-Lo Presti standard (82.05%). The Chi square test showed that Peguero-Lo Presti standard had the best accuracy and sensitivity (P<0.05), the difference was statistically significant, but in the specificity, although Cornell standard was the highest, the three standards had no significant difference in diagnosis specificity (P=0.068). The Kappa test showed that the highest kappa value of Peguero-Lo Presti standard was 0.540, which was consistent with the gold standard. The AUC value of Peguero-Lo Presti standard was 0.886, which was the most significant for the diagnosis of LVH. Conclusion According to all the indexes, Peguero-Lo Presti voltage standard is the most valuable and simple in diagnosis of LVH, which is worthy of clinical application and promotion.