Abstract: Objective To investigate the effects of Jianpi Hewei Granule combined with conventional western medicine on symptoms, psychology and immune status in patients with chronic non-atrophic gastritis of spleen deficiency and Qi stagnation. Methods A total of 97 patients with spleen-deficiency Qi stagnation type CNAG who were diagnosed in our hospital from June 2018 to April 2019 were enrolled. All patients were divided into a combination group (48 cases) and a control group (49 cases) according to the random number table method. All patients underwent Helicobacter pylori examination after diagnosis. The positive patients received rabeprazole+amoxicillin+clarithromycin+colloidal pectin quadruple therapy, while the negative patients received rabeprazole + colloidal pectin. The treatment time was 2 weeks, and the combined group was given Jianpi Hewei Granules. The difference between the two groups of patients after treatment, the difference between symptom score, psychological function score, immune function index and adverse reaction rate before and after treatment. Results After treatment, the combined group efficacy was better than the control group, the difference was statistically significant (P<0.05). After treatment, the combined gastroscope pathological score was better than the control group, the difference was statistically significant (Z=4.370, P=0.038). The HAMA score and HAMD scores of the patients in the combined group (8.74±1.19 and 8.03±1.14) were lower than those in the control group (11.32±2.47 and 11.04±2.98), and the difference was statistically significant (t=-6.531, -6.544; all P<0.05). The proportions of NK, CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺ in the combined group were significantly higher than those in the control group (all P<0.05). There was no statistically significant difference in the occurrence of various adverse reactions between the two groups of patients (all P>0.05). Conclusion Jianpi Hewei Granules can be used to treat patients with spleen deficiency and Qi stagnation type CNAG. It can improve the patient's anxiety and depression, improve immune function and safety.