Abstract: Objective To explore the intervention effect of rational behavior replacement nursing on the elderly patients with BPH. Methods From January 2018 October 2018, 73 patients with BPH were admitted to ZhuJi People's Hospital Jiangdong Branch Urology. According to the method of random number table, the patients were divided into observation group (37 cases) and control group (36 cases). The nursing effect of the two groups was compared. The outcome measures included:compliance rate, postoperative complications. Results In the observation group, the compliance score[2.54±0.61, 2.74±0.52, 2.83±0.66, 2.75±0.28] and compliance rate (94.60%) were higher than those in the control group[2.11±0.53, 2.16±0.39, 1.97±0.45, 2.14±0.37, 77.78%]. There was a statistically significant difference between the two groups in scores of self-reported mood, reasonable daily activities, scientific diet and adequate water intake (all P<0.05), and the incidence of postoperative complications such as bladder spasm and urinary tract infection (5.41%) were significantly higher than those in the control group (19.44%) There was no statistical significance (χ²=2.155, P=0.142). Conclusion Reasonable behavior replacement nursing can improve the compliance behavior of elderly patients with BPH, reduce the incidence of postoperative complications, and has the value of clinical application.