强迫性障碍患者的脑功能活动特点及丘脑与全脑功能连接分析

牛琪惠; 牛明敏; 张力方; 刘俊宏; 程敬亮; 杨磊; 李幼辉

doi:10.16766/j.cnki.issn.1674-4152.001483

强迫性障碍患者的脑功能活动特点及丘脑与全脑功能连接分析

doi: 10.16766/j.cnki.issn.1674-4152.001483

1. 郑州大学第一附属医院精神医学科, 河南郑州 450052;
2. 郑州大学第一附属医院磁共振科;
3. 郑州铁路职业技术学院组织部, 河南郑州 450000

基金项目:

西部精神医学协会科研基金(Wcpafund-201608)

河南省科技重大攻关项目(142102310512)

详细信息

通讯作者:
李幼辉,E-mail:qiuliyouhui@126.com

中图分类号: R749.7
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出版历程
- 收稿日期: 2019-09-22
- 网络出版日期: 2022-08-06

Study on characteristics of brain activity and the functional connection between thalamus and whole brain in obsessive-compulsive disorder patients

Department of Psychiatry,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,He'nan 450052,China

摘要

摘要: 目的比较静息状态下强迫性障碍患者脑功能活动与健康对照的差异,并分析患者双侧丘脑与全脑功能连接模式的特点。方法按照ICD-10中强迫性障碍的诊断标准,选取26例强迫性障碍患者(OCD组)和性别、年龄、受教育程度相匹配的25例健康志愿者(HC组),分别进行Y-BOCS、HAMA、HAMD量表测验和大脑功能磁共振扫描。在全脑体素水平上进行ReHo分析,筛选出2组间ReHo值有差异的脑区,分别以左右两侧丘脑作为种子点进行全脑功能连接分析。结果将统计阈值设置为P<0.005,激活体素>1 512 mm³,Alphasim校正(P<0.005),结果显示OCD组与HC组ReHo值有差异的脑区:左侧丘脑、右侧丘脑、右侧中央旁小叶、右侧中央后回、左侧角回。将左侧丘脑作为种子点的脑功能连接分析,OCD组较HC组功能连接减弱的脑区:双侧丘脑、左侧额中回、右侧海马、右侧尾状核;OCD组较HC组功能连接增强的脑区:双侧中央前回、左侧顶叶、双侧颞叶、双侧中央后回、双侧距状回、双侧舌回、双侧楔前叶、双侧楔叶、双侧小脑、右侧梭状回、双侧中央旁小叶。将右侧丘脑作为种子点的脑功能连接分析,OCD组较HC组功能连接减弱的脑区:左侧额中回、右侧额上回、双侧丘脑、双侧前扣带回、双侧中扣带回、右侧缘回;OCD组较HC组功能连接增强的脑区:双侧颞叶、双侧枕叶、双侧小脑、双侧楔叶、左侧梭状回、双侧舌回、双侧距状回。结论强迫性障碍患者多个脑区功能活动异常,边缘CSTC环路功能连接减弱,丘脑与大脑中后部出现代偿性功能连接增强。
- 强迫性障碍 /
- 功能磁共振 /
- 功能连接
Abstract: Objective To investigate the characteristics of brain functional activities in obsessive-compulsive disorder(OCD) patients compared with healthy controls in resting state, and to explore the functional connection patterns between bilateral thalamus and whole brain in patients. Methods According to the diagnostic criteria of OCD in ICD-10, 26 patients with OCD(OCD group) and 25 healthy volunteers(HC group) matched in gender, age and education background were selected for Y-BOCS, HAMA, HAMD scale tests and brain functional MRI scans. ReHo analysis was carried out at the whole brain voxel level, and brain regions with different ReHo values between the two groups were screened. The left and right thalamus were used as seed points for the analysis of the whole brain functional connection. Results Brain regions with different ReHo values between OCD group and HC group included left thalamus, right thalamus, right paracentral lobule, right posterior central gyrus and left angular gyrus. Taking left thalamus as the seed point for the analysis of brain functional connectivity, compared with HC group, the OCD group showed weaker functional connectivity in bilateral thalamus, left frontal middle gyrus, right hippocampus and right caudate nucleus, and showed enhanced functional connectivity in bilateral anterior central gyrus, left parietal lobe, bilateral temporal lobe, bilateral posterior central gyrus, bilateral calcarine gyrus, bilateral lingual gyrus, bilateral precuneus, bilateral cuneus, bilateral cerebellum, right fusiform gyrus and bilateral paracentral lobule. Taking right thalamus as the seed point to analyze the connections of the brain, the OCD group, compared with HC group, showed weaker functional connectivity in left medial frontal gyrus, right superior frontal gyrus, bilateral thalamus, bilateral anterior cingulate gyrus, bilateral medial cingulate gyrus, and right marginal gyrus, and showed enhanced functional connections in bilateral temporal lobe, bilateral occipital lobe, bilateral cerebellum, bilateral cuneus lobe, left fusiform gyrus, bilateral lingual gyrus and bilateral Calcarine gyrus. Conclusion Patients with OCD have abnormal functional activities in multiple brain areas, weakened functional connections in the limbic CSTC loop, and enhanced compensatory functional connections between the thalamus and the middle and posterior parts of the brain.
- Obsessive-compulsive disorder /
- Functional magnetic resonance imaging /
- Functional connectivity