Abstract: Objective To explore the effect of health management combined with calcitriol based on progressive resistance training on CTX(type I procollagen peptide), BAP(bone specific alkaline phosphatase) and fall risk in postmenopausal osteoporosis women. Methods Total 96 postmenopausal osteoporosis patients treated in our hospital from March 2018 to May 2019 were included in the study. They were divided into two groups according to the digital random table method. The observation group(48 cases) took health management based on progressive resistance training combined with calcitriol intervention. The control group(48 cases) received calcitriol intervention. The changes of BAP and CTX and the fall risk score before and after the intervention in the two groups were observed. Meanwhile, the changes of hip BMD and femoral trochanter BMD before and after the intervention in the two groups were counted. Results There was no significant difference in BAP and CTX levels between the two groups before and after intervention(all P>0.05). After the intervention, the lumbar bone density of the observation group was significantly increased(P<0.05), but the lumbar bone density of the control group was not significantly increased(P>0.05), and the lumbar bone density of the observation group after the intervention was better than that of the control group(P<0.05). There was no significant difference in hip bone density and femoral trochanter bone density between the two groups before and after the intervention(all P>0.05). After 6 months of intervention, the fall index in the observation group was significantly better than that in the control group(P<0.05). BAP, CTX were significantly positively correlated with fall index score(all P<0.05). Conclusion Health management based on progressive resistance training combined with calcitriol has a good improvement effect on CTX, BAP and fall risk of postmenopausal osteoporosis women, and can enhance the prevention of fall risk compared with conventional drugs. It has high clinical application value and is worthy of clinical promotion and wide application.