Abstract: Objective To explore the effect of comprehensive health care intervention of traditional Chinese medicine on the improvement of bone mineral density in postmenopausal women with low bone mineral density. Methods Total 124 postmenopausal patients with low bone mineral density in our hospital from January 2016 to January 2018 were randomly divided into observation group and control group, 62 cases in each group. The control group was given calcium carbonate D3 + regular diet and activities for 6 months. The observation group was given comprehensive health care intervention of traditional Chinese medicine for 6 months. The differences of bone mineral density and bone metabolic markers between the two groups before and 6 months after treatment were compared. Results Compared with that before treatment, the bone mineral density of the control group(0.57±0.07) was significantly higher(P<0.05), and the bone mineral density of the 1 st-4 th lumbar vertebrae(0.77±0.06), femoral neck(0.75±0.07), femoral trochanter(0.61±0.08) and wards triangle(0.60±0.09) in the observation group were significantly higher(P<0.05). In the control group,the levels of carboxy terminal peptide β special sequence[(0.49±0.06)ng/mL], blood calcium[(2.28±0.07) mmol/L] and bone specific alkaline phosphatase[(326.37±100.82) U/L]were significantly higher than that before treatment(P<0.05). In the observation group, the levels of amino terminal peptide[(50.13±12.76) ng/mL], middle molecular fragment of osteocalcin[(21.24±6.77) ng/mL], and bone specific alkaline phosphatase[(418.72±129.90) U/L] were significantly higher(all P<0.05), while the levels of carboxy terminal peptide β special sequence[(0.43±0.09) ng/mL] and blood calcium[(2.21±0.07) mmol/L] were decreased significantly(P<0.05). Compared with the control group, the bone mineral density and bone metabolic markers of the observation group were significantly improved(all P<0.05). Conclusion The comprehensive health care intervention of traditional Chinese medicine can improve the bone mineral density of postmenopausal patients with low bone mineral density in a short time, and improve the expression level of bone formation markers and bone resorption markers.