Abstract: Objective To analyze the results of the general surgery examination of Guangdong Medical University in the 2016-2018 academic years, in order to explore the effectiveness of the reform and provide a reference for further improving the quality of teaching. Methods The final exam scores of classes in the general surgery course offered by Guangdong Medical University since the 2016 academic year was collected and analyzed. The differences between the overall assessment scores, roll scores, and time grades in different academic years, grades, majors, and genders were analyzed. The linear mixed model was used to analyze the roll score. Results A total of 1 359 people took the general surgery examination in the 2016-2018 academic years. The average scores of the usual scores, roll scores, and overall assessment scores were 85.28±3.98, 68.29±8.55, and 73.50±6.22, respectively. The pass and excellent rate were 84.69%(95% CI:82.78-86.60) and 43.34%(95% CI:40.71-45.97). The results of the generalized linear mixed model showed that female, the specialty is clinical medicine, and the 2017 and 2018 academic years have a higher roll score of the general review of surgery is higher, with OR values of 5.492(95% CI:3.146-9.586),9.575(95% CI:1.561-58.720),14.211(95% CI:6.075-33.243)and 2 157.272(95% CI:1 062.993-4 378.034), respectively. Conclusion A series of clinical teaching reforms that have been implemented since 2016 have achieved certain results, but students' grasp of theoretical knowledge still needs to be improved.