Abstract: Objective To explore a scientific, objective, and efficient hospital infection management mechanism. Methods Based on the blue dragonfly nosocomial infection management system, LIS, HIS, PACS, EMR, PDA, and OA system, a reasonable and efficient hospital infection management system of monitoring, quality control, evaluation and feedback was developed. The false negative rates, implementation rate of multi resistant bacteria prevention and control measures, hospital infection knowledge training participations rates, incidence of equipment related hospital infection, supervision of hospital infection, supervision of infectious diseases, effectiveness of monitoring results of disinfection and sterilization effect were compared through the application of the information management system. Results After using information hospital infection management system,the false negative rates, implementation rate of multi resistant bacteria prevention and control measures, hospital infection knowledge training participations rates were reduced to 0.0%, 96.3%, and 97.1% from 19.0%, 78.2%, and 79.2%. The infection rates of VAP, CLABSI, and CAUTI were reduced to 4.51‰, 1.96‰ and 2.79‰ from 14.52‰, 3.91‰ and 6.90‰. But the incidence of CLABSI was relatively high as compared with the class 35 hospital ICU of china, thus it should put emphasis on the constitution of the CLABSI interventions. The supervision of hospital infection, supervision of infectious diseases, effectiveness of monitoring results of disinfection and sterilization effect increased significantly. Conclusion The application of hospital infection management mechanism relying on the informatization can effectively improve the whole quality of hospital infection management and management efficiency.