Abstract: Objective To explore the effect of cluster intervention on in-hospital transport of critical patients in emergency department. Methods A total of 100 patients who were admitted to the emergency department from June 2017 to May 2018 were selected as the control group, and the routine nursing measures were adopted. As an observation group, 100 critically ill patients transported to the hospital from June 2018 to May 2019 were treated with cluster intervention. Statistical analysis of the incidence of adverse events, average transfer time, patient/family, the satisfaction of medical staff in receiving department, the change of patients,condition and the success rate were performed during the two groups of patients. Results The incidence of adverse events in the control group was 18.0%, higher than the observation group's 7.0%, and the difference was statistically significant(P<0.05). The average transit time in the control group was(14.57±2.16) min higher than(10.12±1.88) min in the observation group. The difference was statistically significant(P<0.05). The Satisfaction score of doctors, patients/families in the control group were 6.23±1.48, 6.03±1.45, which were lower than the observation group's 7.08±1.35, 7.35±1.36, the difference was statistically significant(all P<0.05). The incidence of change in condition in the control group was 23.0% higher than that in the observation group's 6.0%; the transfer success rate in the control group was 79.0% lower than the observation group's 93.0%, and the difference was statistically significant(all P<0.05). Conclusion Clustering interventions can reduce the incidence of adverse transport events in hospitals for critically ill patients from department of emergency surgery, shorten the transport time, reduce the incidence of disease changes in patients during the transport process, and improve the satisfaction level of doctors and patients and the success rate of transport.