Abstract: Objective To investigate the effect of modified oral endotracheal intubation fixation on instrumental pressure injury of oral, facial and neck in patients with clinical ICU. Methods A single-center, prospective, randomized controlled research method was used to select 80 patients who were admitted to the ICU ward of the Third People's Hospital of Bengbu City from June 2019 to March 2020, and were fixed by the method of oral tracheal intubation. Random number table method was used to randomly divide them into an observation group and a control group, with 40 patients in each group. The observation group adopts the modified tracheal intubation fixation method, and the control group adopts the conventional tracheal intubation fixation method. Compare the location and severity of device-related pressure injury in the mouth, face, and neck of the two groups of patients. Results The two groups of patients showed no significant difference in age, endotracheal intubation time, Braden scale score, muscle strength and other indicators(all P>0.05). A total of 3 cases(7.5%) of oral, facial and neck pressure injuries occurred in the observation group; 15 cases(37.5%) of pressure, oral, facial and neck pressure injuries occurred in the control group. The number and proportion of injuries in the observation group were significantly less than those in the control group. After statistical analysis, the difference was statistically significant(all P<0.05). Conclusion Compared with the control group, the observation group using the modified oral endotracheal intubation fixation method can significantly reduce the incidence and severity of patients with oral, facial and neck instrumental pressure injury. This has a great help in effectively reducing the iatrogenic complications that persist in the mouth, face, and neck of ICU patients, such as redness, pain, ulceration, infection, and necrosis. It greatly enhances the confidence of patients to restore health, and has great practical guiding significance for clinicians and nursing managers.