Abstract: Objective Mechanical thrombectomy is a new method of endovascular therapy, with good effect in the treatment of acute ischemic stroke. To explore the clinical prognostic factors of acute ischemic stroke patients after mechanical thrombectomy. Methods Total 87 patients with mechanical thrombectomy in our hospital from January 2017 to December 2018 were included in our research. The modified Rankin Scale(mRS) scores was regarded as prognosis assessment at 90 days. The mRS scores ≤ 3 points were considered good prognosis(44 cases), mRS scores 4-6 points were considered poor prognosis(43 cases). Multivariate Logistic regression was used to investigate the prognosis. Results There were significant differences in age and National Institutes of Health Stroke Scale(NIHSS) scores(both baseline and 24 h post-operative) of the patients between the good and the poor prognosis group(all P<0.05). Multivariate Logistic regression analysis showed that the age, baseline and 24 h post-operative NIHSS scores were risk factors for poor prognosis of mechanical thrombectomy(Baseline NIHSS score: OR=1.820, 95% CI=1.19-2.77, P=0.005; Post-operative NIHSS score: OR=2.006, 95% CI=1.30-3.10, P=0.002; Age: OR=1.102, 95% CI=1.04-1.17, P=0.001). Conclusion NIHSS scores and age are independent risk factors for prognosis of acute ischemic stroke patients treated with mechanical thrombectomy.