Abstract: Objective To explore the influence of Wuqinxi on disease activity level, activity of daily living and self-rating depression and anxiety scale of the rheumatoid arthritis(RA) patients. Methods Total 100 patients with RA admitted to our hospital from January 2018 to January 2019 were randomly divided into control group(50 cases) and Wuqinxi group(50 cases). The control group was given routine interventions(stable dose of glucocorticoid and remission of disease anti-rheumatic drugs), and the Wuqinxi group was given Wuqinxi twice a day for 30 minutes on the basis of the routine interventions. After 2 months of follow-up, the disease activity DAS28, activity of daily living, self-rating depression and anxiety scale of the two groups were analyzed. Results Total 100 patients with RA admitted to our hospital from January 2018 to January 2019 were randomly divided into control group(50 cases) and Wuqinxi group(50 cases). The control group was given routine interventions(stable dose of glucocorticoid and remission of disease anti-rheumatic drugs), and the Wuqinxi group was given Wuqinxi twice a day for 30 minutes on the basis of the routine interventions. After 2 months of follow-up, the disease activity DAS28, activity of daily living, self-rating depression and anxiety scale of the two groups were analyzed. Conclusion The application of Wuqinxi in RA patients does not cause aggravation of disease activity, but it can improve patients' activity of daily living, anxiety and depression scores, and quality of life.