Abstract: Lumbar disc herniation, lumbar spinal stenosis and other interverbral degenerative diseases are the main causes of low back pain. For patients who have failed conservative treatment, fusion is the main way to treat this type of disease. Coflex is a kind of dynamic stabilization system between spinous processes. The device realizes the dynamic stability of the degenerative segment and retains the motion of lumbar spine. Compared with fusion, it cannot only relieve the clinical symptoms of patients, but also avoid the occurrence of fusion-related complications such as the disappearance of surgical segment mobility and the degeneration of adjacent segments. For multi-segment lumbar degeneration, the Topping-off procedure shows a unique advantage, which can reduce the risk of disc degeneration in adjacent segments. In recent years, research on Coflex has been deepened and the safety and effectiveness of the Coflex system have been continuously recognized, but there is still a lack of high-level, large-sample and multi-center clinical research as a support. Clinicians have continuously improved Coflex in their applications and developed new interspinous process dynamic stabilization devices. Therefore, in order to provide a reference for the clinical application of the Coflex system, this article reviews the indications and contraindications of the Coflex system, biomechanical characteristics, clinical efficacy, postoperative complications, and the development of new dynamic stabilization devices.