Abstract: Objective To explore the effect of staged cognitive behavioral intervention on patients with bronchogenic carcinoma undergoing chemotherapy. Methods A total of 72 patients with bronchogenic carcinoma treated by chemotherapy at the Medical Oncology of Bozhou City People's Hospital from August 2017 to December 2018 were randomly divided into group routine nursing(Group RN, 36 cases) and group cognitive behavioral intervention(Group CBI, 36 cases).Both RN group and CBI group were given routine nursing of chemotherapy. On this basis, the CBI group were received cognitive behavioral intervention through three stages: cognitive correction, behavior therapy and consolidation exercise. The quality of life and psychological status of patients in two groups were evaluated and compared at the time of admission and discharge. Results After intervention, SF-36 in CBI group got better scores in the psychological states, physiological ability, adaptive capacity to environment and social capacity than those in RN group(48.53±2.34 vs. 45.69±2.18,46.89±2.81 vs. 42.15±2.26, 44.65±2.45 vs. 41.23±2.56, 58.65±2.44 vs. 54.35±2.64, respectively, all P<0.01),and the scores of SAS and SDS in CBI group decreased significantly after intervention(58.79±5.66 vs. 39.05±4.11, 61.76±4.87 vs. 38.03±4.05, respectively, all P<0.01). Conclusion After the staged cognitive behavioral intervention applying to patients with bronchogenic carcinoma undergoing chemotherapy, the quality of life is significantly increased and the state of anxiety and depression is improved.