Abstract: Objective To analyze the application effect of path-based nursing intervention in patients with deep vein thrombosis catheter thrombolysis of lower extremity, aiming to provide basis for improving the effect of catheter thrombolysis. Methods A total of 84 patients with deep venous thrombosis of lower extremities admitted in our hospital from July 2017 to December 2019 were selected and divided into two groups according to the digital random table method, that is, 42 cases in the control group and routine care, 42 cases in the observation group and pathology Nursing intervention. The rehabilitation status of the two groups of patients(detection of patients' rehabilitation time, hospitalization time, hospitalization cost), health knowledge level(health education knowledge scale made by our hospital department), coagulation function(determination of fibrinogen, thrombin time, Prothrombin time) and satisfaction rate were compared. The incidence of postoperative complications of patients(catheter blockage, catheter shedding, wound infection, bleeding, etc.) were analyzed. SPSS 23.0 statistical processing data was used for the specific data of the two groups. Results The recovery time and hospitalization time of the observation group were shorter than that of the control group(t=6.972, 5.245, all P<0.05). The hospitalization cost was lower than that of the control group(t=5.997, P<0.05). The content of posterior fibrinogen was lower than that of the control group(t=7.441, P<0.05). Thrombin time, prothrombin time, APTT were longer than the control group, the difference was statistically significant(t=11.121, 11.387, 6.355; all P<0.05). The observation group's post-nursing health education knowledge score was higher than that of the control group(t=5.835, P<0.05). The incidence of complications in the observation group was 2.38%, lower than that of the control group, 23.81%, the difference was statistically significant(χ²=8.372, P=0.004). The nursing satisfaction rate in the observation group was 97.62%, higher than that in the control group, 76.19%, the difference was statistically significant(P<0.05). Conclusion Path-based nursing intervention can reduce the incidence of complications in patients with deep vein thrombosis catheter thrombolysis of lower extremities, improve the rehabilitation effect, and improve the coagulation function of the body, which is worthy of application.